EIF4EBP1 and nonpapillary renal cell carcinoma: The results showed that the level of mTORC1 signaling in ccRCC was not different from its levels in pair-matched normal renal tissue, given that the phosphorylation of primary mTORC1 targets (phospho-p70 S6 Kinase (Thr389), phospho-S6 (S235/236), and phospho-4E-BP1 (Thr37/46)) was not significantly increased in ccRCC samples relative to normal renal tissue.