CYB5R2 and myeloid sarcoma: RT-qPCR validation of CYB5R2, a gene encoding for a protein involved in cholesterol biosynthesis, showed a strong reduction in expression levels among MS samples when compared with non-MS controls (*** p < 0.001; Figure 5E), an effect that was visible across all the tested MS subtypes (* p < 0.05 for RRMS, ** p < 0.01 for SPMS and PPMS, respectively; Figure 5E′).