INS and diabetes mellitus: There are several factors that increase hypoglycemia risk in diabetes, such as the use of insulin or sulfonylureas, impaired renal or hepatic function, diabetes duration, frailty and old age, cognitive impairment, impaired hypoglycemia awareness, a physical or intellectual disability that impairs behavioral response to hypoglycemia, alcohol use, polypharmacy, and history of severe hypoglycemia [2].