In patients with insulin-treated T2D and established cardiovascular disease or cardiovascular risk factors undergoing 5 days of concomitant CGM and ECG monitoring, the incidence of bradycardia was eightfold higher, and the incidence of atrial and ventricular ectopic beats was fourfold higher during nocturnal hypoglycemia compared with nocturnal normoglycaemia [38]. This evidence concerns the gene INS and type 2 diabetes mellitus.