In 23 patients (3.5%), autosomal recessive (AR) deficiencies (IRF7 and IFNAR1) and autosomal dominant (AD) deficiencies (TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, and IFNAR2) were identified. This evidence concerns the gene IRF7 and Alzheimer disease.