For instance, using cultured cells in the presence of high glucose content, supplementation of the media with nicotinamide riboside induced Sirt3, GPx1 and SOD2 and cell viability [235], suggesting that Sirt3 may play a role in increasing antioxidant defense to provide resistance against hyperglycemia-associated oxidative stress. This evidence concerns the gene SIRT3 and Hyperglycemia.