PRRT2 and Insulin resistance: 3.2. Glucose collateral metabolism 3.2.1. PKC pathway. Increase in DAG formation and activation of NOX isoenzymes.3.2.2. Polyol pathway. Sorbitol and fructose formation, cofactor imbalance. 3.2.3. Hexosamine pathway. O-NAcGlucNH2 glycosylated proteins, ER stress and insulin resistance.