Here, the expression of Defb3 and Defb14 (orthologous of hBD-2 and -3, respectively) significantly increased in the skin of untreated NC/Nga mice with atopic dermatitis compared with control mice, while the expression of Defb1, a homolog of hBD-1, tended to increase, although not significantly (p = 0.1247). The gene discussed is DEFB1; the disease is atopic eczema.