Following in the VM production by tumor cells, recently, our group reported that FAK plays an essential role in the acquisition of VM property, permitting the union of VE-cadherin to β-catenin/TCF-4 (Transcription factor-4) to enhance the transcription activity from TCF-4 dependent genes (c-Myc, Twsit-1, and S1PR1) [122]. Here, TCF4 is linked to neoplasm.