Na Hu et al., 2017 in their study of 80 patients with HBV-related HCC, showed hypomethylation of the UBE2Q1 gene in the sera of HBV-associated HCC patients and also noted a negative correlation between UBE2Q1 gene methylation and the TNM stage of the tumor [123]. Here, UBE2Q1 is linked to hepatocellular carcinoma.