It has been demonstrated that DAX1 (NR0B1), an orphan nuclear receptor, is induced by the EWS/FLI1 oncoprotein and is highly expressed in Ewing’s tumors, suggesting that DAX1 is a biologically relevant target of EWS/FLI1-mediated oncogenesis [4]. Here, NR0B1 is linked to Ewing sarcoma.