Dyslipidemia and ectopic fat in insulin-sensitive cells can induce insulin resistance via the increased accumulation of free fatty acids (FFAs), triglycerides (TGs), low-density lipoproteins (LDLs) and very-low-density lipoproteins (VLDLs), which, in turn, cause lipotoxicity [51,52]. This evidence concerns the gene INS and Insulin resistance.