In line, baicalin was found to effectively alleviate the development of obesity by inhibiting the expression of p-p38 mitogen-activated protein kinase (MAPK), phosphorylation cyclic adenosine 3′,5′-monophosphate (cAMP) response binding protein (p-CREB), forkhead transcription factor forkhead box O1A (Foxo1), peroxisome proliferator-activated receptor γ coactivators 1α (PGC-1α), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase) in the liver of obese mice and hepatocytes [35]. The gene discussed is G6PC1; the disease is obesity due to melanocortin 4 receptor deficiency.