In animal models, it has been shown that, after intravenous administration of ascorbate, H2O2 is detected in extracellular fluid [132], the excretion of ascorbate from the tumor is significantly prolonged, and the pro-oxidant damaging effect on cancer cells is reinforced by the suppression of the transcription factor HIF-1 [153]. The gene discussed is HIF1A; the disease is neoplasm.