It should be noted that, according to the information reported by the cBioPortal for cancer genomics, the human RB1 gene, as well as the genes encoding CDK4 (CDK4), CDK6 (CDK6), and cyclin D1 (CCND1), are all expressed in AGS and MCF-7 cells, without mutations reported so far (Table S1). Here, CCND1 is linked to cancer.