This study involved RNA-Seq profiling of 58 LPCa samples from intermediate- and high-risk groups and 43 locally advanced PCa (LAPCa) samples from a cohort of Russian patients, with the aim of identifying transcriptional profile differences between these groups, taking into account the TMPRSS2-ERG subtype, and searching for promising genes as prognostic markers. Here, TMPRSS2 is linked to posterior cortical atrophy.