MYC and neoplasm: There is also experimental evidence that lipogenesis in tumors, associated with increased expression of the fatty acid synthase gene (FASN), is strongly dependent on the activity and/or expression of important oncogenes and tumor suppressors, including MYC, which cooperates with the sterol regulatory element-binding proteins (SREBPs) and can induce in vitro and in vivo lipogenesis, thus playing an important role in initiating and maintaining oncogenic growth [32].