PRKAA1 and type 2 diabetes mellitus: In another study, daily treatment with resveratrol (3 g/day for 12 weeks) enhanced energy expenditure by increasing SIRT1 expression and p-AMPK/AMPK ratio in the SKM of overweight patients with type 2 diabetes [161]; however, the possible involvement of SIRT1 in the effects of resveratrol in the adipose tissue has not been investigated.