Worthy of note, the daily intake of polyphenol-rich bergamot juice (24% v/v for 3 weeks) reduced PPAR-γ expression and up-regulated PGC-1α and UCP1 genes in the WAT of rats fed with a HF diet, probably by increasing plasma levels of the myokine irisin [131]. This evidence concerns the gene PPARGC1A and hydrops fetalis.