ITGA2B and Thrombocytopenia: To investigate whether EIII-SNPs could induce a worsened thrombocytopenia phenotype in vivo, C57BL/6J mice were subjected to first-hit treatments of GST, EIII, SNPs, GST-SNPs, and EIII-SNPs for 24 h, and then followed by additional 24 h second-hit treatment of antiplatelet (anti-CD41) antibody.