In food-dependent Cushing’s syndrome (FDCS), the ectopic expression of GIPR has been associated with the inversed rhythm of cortisol secretion [9], while in neuroendocrine tumors (NET), the incidence/density of GIPR may correlate with increasing proliferative rates [8,10] and the development of metastasis [11]. The gene discussed is GIPR; the disease is ACTH-independent macronodular adrenal hyperplasia 3.