IL37 and bladder transitional cell carcinoma: Lastly, one always needs to bear in mind that even though IL-37 and its partners may play a protective role against tumor development, such as the possible role indicated in the case of BLCA, there are other types of malignancies where this cytokine acts in favor of tumor growth, mediating a series of processes, and/or is associated with unfavorable predictors of the diseases, as described in the introduction of this manuscript.