Additionally, recombinant IL-37 hampers the immunosuppressive effect of HCC cells against DCs, which is demonstrated by the increased expression of the surface molecules MHC-II, CD86 and CD40, while it stimulates DCs to secrete IL-2, IL-12, IL-12p70, interferon-a (IFN-α) and IFN-γ, further enhancing the anti-tumor effect of T cells. This evidence concerns the gene IL37 and hepatocellular carcinoma.