MAPT and Alzheimer disease: This includes lines 3xTg-AD by LaFerla and colleagues, which combine several AD-related mutations [33,34], and the line rTg4510, which expresses human 0N4R-Tau with the P301L mutation at a high level (~13× endogenous tau) and in an inducible fashion, created by Ashe and coworkers [8,9].