MAPT and tauopathy: Using a mouse model of tauopathy expressing human full-length tau with ΔK280 mutation (TauΔK), we had shown previously that the adenosine A1 receptor antagonist rolofylline (KW-3902) was able to restore spatial memory deficits and normalized the basic synaptic transmission of 14-month-old TauΔK transgenic mice [22].