We analyzed and highlighted the difference between overexpressing and silencing TELO2 in normal and GBM cells in Hallmark gene sets (Figure 4A) involved in oncogenic functions, including E2F targets and G2-M checkpoints (related to the cell cycle), epithelial–mesenchymal transient (EMT), and the reactive oxygen species (ROS) pathway, via GESAs (Figure 4B). The gene discussed is TELO2; the disease is glioblastoma.