We highlighted the difference between overexpressing and silencing the TELO2 of normal and GBM cells in the Kinetochore Assembly, mTOR Signaling, Oncogene-Induced Cellular Senescence, and Proteins Involved in Astrocytoma gene set to conduct further analysis based on our previous findings of TELO2 overexpression in human high-grade gliomas. This evidence concerns the gene TELO2 and central nervous system cancer.