We determined susceptibility of KC to VV and HSV-1 infection after exposure to representative cytokines prevalent in diverse inflammatory cutaneous diseases: IFNγ (lupus/AD; type 1), IL-4 and IL-13 (AD; type 2), IL-22 and IL-17A (psoriasis/AD, type 3). Here, IL4 is linked to systemic lupus erythematosus.