Evaluation of miR-182-5p, Cyld and Foxo1 expression levels in peritumor vs. tumor hepatic tissues (GSE22058 datasets), based on the GEO2R tool, demonstrated not only significant miR-182-5p upregulation, but also concomitant Cyld and Foxo1 downregulation in cancer samples (Figure 4a). The gene discussed is CYLD; the disease is cancer.