PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Genetic factors, particularly genetic polymorphisms, which appear to be involved in NAFLD (e.g., the patatin-like phospholipase domain-containing 3 (PNPLA3) I148M variant and transmembrane 6 superfamily member 2 (TM6SF2) E167K variant) have also been described [15,16].