Cyld negatively regulates NF-kB, known to be one of the most important players in inflammation and liver cancer [57], and the MAPK signaling cascade [58,59] by removing ubiquitin chains from signaling molecules, such as NEMO, TRAF2, TRAF6, TRAF7, TAK1 and RIP1 [60]. This evidence concerns the gene CYLD and liver cancer.