Similarly, NLRP3-associated IL-18 is found in high levels in plasma of lymphoma [142] and multiple myeloma patients where IL-18 is a predictor of poor survival in multiple myeloma patients [149,158], esophageal carcinoma [159], renal cell carcinoma [160] and gastric carcinoma [161]. The gene discussed is NLRP3; the disease is AL amyloidosis.