In AOM/DSS-induced colon cancer, it has been shown that IL-18 levels were decreased in tumor-bearing mice [95], that the NLRP3/ASC/CASP1/IL-18 axis was important to dampen tumor growth [95,96] and this was dependent on IFN-γ production [97]. The gene discussed is IFNG; the disease is malignant colon neoplasm.