IL18 and melanoma: In vitro studies have shown that the migration ability and proliferation of human leukemic cells, lymphoma [142,143], human gastric cells and murine melanoma was dependent on their production of IL-18 in a NLRP3/caspase-1-dependent manner through VEGF production [144,145,146], and this was further increased when cells were treated with recombinant IL-18 [147].