Levels of IL-18 and IFN-γ were shown to be lower in plasmas of non-small cell lung cancer patients [126] and in tumor tissue of colon cancer, melanoma, thyroid and esophageal cancer patients compared to those of healthy subjects, and low levels of IL-18 correlated with the presence of metastases, a poor outcome [127,128,129,130,131] and increased risk of developing acute myeloid leukemia [132]. This evidence concerns the gene IL18 and neoplasm.