IL-18 would have a different effect depending on the cell type, which demonstrated by the facts that human pancreatic tumor tissue expresses high levels of IL-18 [152,153,156,157] and low levels of IL-18BP [156] and these are linked to shorter survival and increased metastasis, whereas high levels of plasmatic IL-18 are associated with a better outcome [152]. This evidence concerns the gene IL18BP and pancreatic neoplasm.