It has been found that hyperglycemia inhibited the AMPK/mTOR/ULK1 pathway, thereby suppressing autophagy and inhibiting the formation and function of osteoclasts [97], whereas activation of the PI3K/AKT/mTOR pathway in diabetic mice reduced the RANKL/OPG ratio of osteoblastic cells, thus alleviating bone resorption [98]. This evidence concerns the gene ULK1 and Hyperglycemia.