Treatment with exosomes carrying miR-140-3p was discovered to improve joint injury as well as reduce chondrocyte cell apoptosis in rats with rheumatoid arthritis (RA) through the targeting of SGK1 [101], while intra-articular injection with UCMSCs previously transfected with miR-140-5p could further induce the chondrogenetic and self-healing capacity of injured cartilage tissue in OA rats [102]. Here, SGK1 is linked to rheumatoid arthritis.