Exosomal miR-377-3p was demonstrated to play a role in the mediation of inflammation in LPS-induced ALI mice by inducing cell autophagy through downregulation of its target gene RPTOR [120], while miR-100 delivery through WJMSC-microvesicles (MVs) appears to function similarly by negatively regulating mTOR expression and increasing autophagy levels in BLM-induced ALI rats [91]. Here, RPTOR is linked to acute respiratory distress syndrome.