Notably, copy number variations and nucleotide mutations in the exon regions differentially influenced disease prognosis and overall survival, with Diazepam Binding Inhibitor (DBI), Carnitine Palmitoyl Transferase 1A (CPT1A), CYP27A1, and Malic Enzyme 1 (ME1), incorporating the four most significant PPAR-related genes linked to endometrial cancer patient prognosis [24]. Here, PPARA is linked to endometrial cancer.