PPARGC1A and cancer: Yoriki et al. concluded that estrogen-related receptor-α/PGC-1α overexpression in Ishikawa and HEC-1A endometrial cancer cells decreased E-cadherin, but upregulated the expression of vimentin, Snail, and Zinc finger E-box Binding homeobox 1 (ZEB1) after exposure to Transforming Growth Factor beta (TGF-β), enhancing cancer cell motility via cancer–stromal interactions [41].