As far as gene expression changes are concerned, the Aldo-Keto Reductase family 1 member C3 (AKR1C3) was found to be upregulated, whereas both the Anterior Gradient Homolog 3 (AGR3) and the Nitric Oxide Synthase 2A (NOS2A) were seemingly downregulated in all three endometrial cancer cell lines [43]. The gene discussed is AKR1C3; the disease is endometrial cancer.