CD274 and melanoma: To analyze the association between the FDX1 expression and anticancer immunotherapy, we studied a gene expression profile for the characterization of the PD-L1 blockade in a melanoma model from the Gene Expression Omnibus (GEO) of the NCBI dataset, and the results negatively correlated high FDX1 expression with immune responses through the GSE172320; however, they showed that increased FDX1 levels were positively related to immune responses via GSE22155 (Figure 5I).