Furthermore, evidence that DREAM plays a role in AD includes: (i) transfection of increasing amounts of DREAM leading to an augmented formation of Aβ42 in HELA cells [64]; (ii) DREAM knock-out mice showing lower levels of Aβ42 peptide in the cerebellum, an area that physiologically expresses high levels of DREAM [38]; (iii) cortical and hippocampal neurons being exposed to Aβ42, upregulating DREAM expression, and causing apoptotic cell death [63]; (iv) DREAM being highly expressed in the brains of AD patients and of Tg2576 transgenic mice [63]. The gene discussed is KCNIP3; the disease is Alzheimer disease.