Interestingly, several lines of evidence have shown that DREAM is downregulated in (i) the striatum and hippocampus of R6/2 and R6/1 mice, two animal models reproducing HD; (ii) the striatal STHdhQ111/111 cell line, derived from knocking-in mice bearing 111 CAG repeats in the huntingtin gene; and (iii) in postmortem brain samples from HD patients. Here, HTT is linked to Huntington disease.