SPHK2 and colonic neoplasm: Given that: (i) miR-125b is directly involved in the progression of colorectal cancer; (ii) CRC is accompanied by alterations in the sphingolipid composition in colon tumours; (iii) SGPP1 promotes disruption of mucosal integrity; (iv) SPHK2 promotes the progression of inflammation by inducing IL-17, we investigated the involvement of miR-125 and the S1P pathway in pathological changes that may predispose patients with primary sclerosing cholangitis to carcinogenesis of colonic tissue.