We observed a positive correlation between HIF-1α and PKM2 in the sigmoid colon of patients with PSC/UC (r = 0.4, p = 0.05) and in both parts of the colons of UC patients (r = 0.7, p = 0.001 and r = 0.5, p = 0.02 in the ascending and sigmoid colons, respectively). This evidence concerns the gene PKM and pancreatic serous cystadenoma.