In high-PCGF1-expressing CRC cells, PCGF1 increased histone H3K4me3 and reduced histone H3K27me3 at the promoter of CD133, CD44, and ALDH1A1 via the H3K4me3 methyltransferase KMT2A and the H3K27me3 demethylase KDM6A, respectively, which collaboratively upregulated the expression of these stemness markers [48]. This evidence concerns the gene PROM1 and colorectal carcinoma.