Glutamine restriction stimulated Rictor/mTORC2 to induce HDAC3-mediated deacetylation and stabilize glutamine synthetase for an enhanced sphere formation, while targeting the mTORC2-HDAC3-glutamine synthetase cascade, which remarkably attenuated the self-renewal of CSCs and facilitated tumor elimination upon glutamine starvation therapy [53]. Here, HDAC3 is linked to neoplasm.