Hyper-O-GlcNAcylated eIF4E, induced by O-GlcNAc transferase (OGT)-endowed HCC cells with stem-like features, as exemplified by their higher proportion of CD133+ hepatoma cells, is a phenomenon possibly achieved through the physical interaction between eIF4E and the untranslated region of SOX2 5′ (5′UTR) [41]. This evidence concerns the gene OGT and hepatocellular carcinoma.