SOX2 and neoplasm: Similarly, FUT9-mediated fucosylation also triggered the stemness reprogramming of CRC, as evidenced by an increase in the CSC marker expression (e.g., Sox2, ALDH, and CD44), tumor-sphere formation, and 5-FU resistance observed in high-FUT9-expressing murine colon adenocarcinoma MC38 cells, human CRC cells, and primary CRC tumors [9].