Similar findings can be observed for esophageal CSCs, in which the highly expressed PRMT1 in esophageal squamous cell carcinoma (ESCC) catalyzed the histone H4R3 arginine asymmetric demethylation to activate the Wnt/β-catenin and Notch signaling pathways for stemness maintenance [45]. Here, PRMT1 is linked to esophageal squamous cell carcinoma.