As for PC, the O-GlcNAcylation of SOX2 catalyzed by OGT was required to maintain its transcriptional activity and stability for stemness phenotypes, whereas the OGT antagonist OSMI-1 efficiently delayed tumor progression by targeting the O-GlcNAcylated SOX2, alone with reduced OCT4 and NANOG levels in subcutaneous xenografts [42]. This evidence concerns the gene NANOG and neoplasm.