TNF and type 2 diabetes mellitus: Visceral white adipose tissue (abdomen and upper body) appears to be the major source of inflammatory markers in type 2 diabetes (cytokines, TNF-alpha, IL-1, IL-6, IL-10, leptin, adiponectin, monocyte chemoattractant protein, angiotensinogen, resistin, chemokines, etc.)[60,61].