TXNIP and endothelial dysfunction: The ROS-sensitive factors, such as protein kinase C (PKC), a metabolic gene implicated in redox balance, and thioredoxin-interacting protein (TXNIP), also enhance the production of glyco/lipoxidation end-products, including AGEs and oxidized LDL, which result in increasing intravascular inflammation and leukocyte recruitment that further contributes to endothelial dysfunction [21,22,23].