Our previous research discussed the expression and regulation mechanism of miR-29a in various diseases, such as liver injury/fibrosis [44,45], diabetic nephropathy [21], osteoarthritis [46], and rotator cuff lesion [40], etc., and has proven that miR-29a significantly affects the expression of IL-6, TGF-β, Dnmt3b [47], TNFSF13b [26], FoXO-3 [48], COL3A1 [49], and more [50]. This evidence concerns the gene IL6 and osteoarthritis.