Another study on 257 patients with type 2 diabetes evaluating five different urine biomarkers showed a higher risk for rapid eGFR loss and progression to ESKD for the highest quartile of urinary KIM-1 among the population (hazard ratio (HR) 2.77, 95% CI, 1.27–6.05) [36]. This evidence concerns the gene HAVCR1 and type 2 diabetes mellitus.