Consequently, the primary objective of this review is to explicate the present state of FUNDC1 in mitochondrial biogenesis, dynamics, and mitophagy, along with the mechanism of the FUNDC1-mediated MQC system in diverse HDs, including metabolic cardiomyopathy, cardiac remodeling/heart failure, and myocardial ischemia-reperfusion injury. This evidence concerns the gene FUNDC1 and heart failure.