AD was also found to be characterized by a negative correlation of miR-155 and suppressor of cytokine signaling 1 (SOCS-1), which stimulates IL-2, IL-3, IL-6 and IFN-γ, and the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway [46]. This evidence concerns the gene SOCS1 and Alzheimer disease.