PFKFB4 and neoplasm: Many glycolytic enzymes are upregulated in cancer cells, and some have been identified as crucial for tumor growth, such as Hexokinase 2 (HK2), aldolase A (ALDOA), pyruvate dehydrogenase kinase 1 (PDK1), Pyruvate Kinase M2 (PKM2), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and Enolase 1 and 2 (ENO1 and ENO2) [40,41].