In the SQ breast tumors, we observed significantly upregulated mRNA levels of the Oct3/4 regulatory network, including ONSS, and several other PTFs, including Nanog, Sall4, Sox2, Sox4, FoxA2, Gata6, Zic2 and HoxB7, as well as Oct3/4 isoform B, polycomb suppressors Bmi1, EzH2, Amigo and Dkk1 (Figure 3A, left panel). This evidence concerns the gene ZIC2 and breast neoplasm.