Differentially expressed transcriptome in the tumors generated from activated Oct3/4 in cancer cells indicate a multipotent stem cell signature associated with heterogeneous tumor sub-populations, including quiescent dormant cells, germ cell progenitors and cells with differentiated markers of endoderm, mesoderm (Vimentin, Snail-EMT genes) and neuroectoderm (Amigo). This evidence concerns the gene POU5F1 and cancer.