Zhao et al. investigated the methylation patterns of TGFB1, BAX, IGFBP3, PRKCB, PSEN2, and CCL2 in the peripheral blood of 42 ASD patients and 26 TD patients, finding that the rate of the methylation of TGFB1 was decreased in ASD and was positively associated with the interaction ability score [50]. This evidence concerns the gene TGFB1 and thanatophoric dysplasia.