For example, dKO and TULA-2 sKO, but not TULA-1 sKO, facilitated secretion of IL-2 and TNF-α in a culture of T cells from colitis-induced mice, while TULA-1 sKO and dKO, but not TULA-2 sKO, facilitated production of IP-10 in these mice in vivo. This evidence concerns the gene UBASH3A and colitis.