Despite the observation of significantly different expression levels of the genes CB1, CB2, FAAH, NAPE-PLD, MAGL, and DAGL in migraineurs compared to HCs, DNA methylation analysis did not show any significant differences between patients with migraine and HCs at the detected CpG sites at the promoter region levels of all the evaluated genes [52]. The gene discussed is CNR2; the disease is migraine disorder.