The IVW method revealed a direct association between increased circulating CRP levels and increased risk of atherosclerosis by 17% (OR = 1.17 [1.05–1.30], p = 0.005) in Approach 1, but not in Approach 2 (OR = 1.10 [0.96–1.26], p = 0.164). This evidence concerns the gene CRP and atherosclerosis.