Using the IVW MR method, we observed that higher CRP levels increase the risk of HF by 9% (OR = 1.09 [1.01–1.18], p = 0.023) in Approach 1, but not in Approach 2 (OR = 1.05 [0.95–1.16], p = 0.342). This evidence concerns the gene CRP and hydrops fetalis.