This finding, low-normal baseline levels of FSH and LH and the presence of correlations between the impact of treatment on both gonadotropins and the degree of reduction in total and monomeric prolactin, suggests that slight changes in gonadotropin levels in women without thyroid disorders reflect the partial normalization of hypothalamic–pituitary–gonadal axis activity, suppressed by chronic prolactin excess [29]. This evidence concerns the gene PLOD1 and thyroid gland disorder.