The ESCAPE discharge risk model (age, blood urine nitrogen, 6 min walking test, sodium, cardiopulmonary resuscitation/mechanical ventilation, diuretic dose, no beta-blocker at discharge, discharge brain natriuretic peptide (BNP)) has been shown to predict the risk of death at 6 months (C-index of 0.739) in a cohort of 423 patients with advanced decompensated systolic HF [30]. This evidence concerns the gene NPPB and hydrops fetalis.