The ADHF/NT-proBNP risk score contains a total of eight variables (chronic obstructive pulmonary disease, systolic blood pressure, eGFR, serum sodium, hemoglobin, NT-proBNP, LVEF, and tricuspid regurgitation moderate to severe), and the possible total score ranges from 0 to 22 [27]. This evidence concerns the gene NPPB and chronic obstructive pulmonary disease.