ANGPT2 and acute respiratory distress syndrome: Several protein biomarkers of ARDS have been described in the literature, including proteins involved in epithelial damage (RAGE, SP-D, and CC16), endothelial permeability (ANG-1, ANG-2, and VEGF), inflammation (IL-6, IL-8, and IL-1RA), and coagulation and fibrinolysis (FiB, PAI-1, and thrombomodulin), among others [68,69].