SCD and cystic fibrosis: Fatty acid dysregulations in CF cells have been explained by the interaction of different mechanisms, such as malabsorption of precursor due to exocrine pancreatic insufficiency, fibrosis-related liver disease, hypoxia affecting fatty acid desaturases, increased flux through the n-6 omega pathway, release of ARA from phospholipids by phospholipase A2, and alterations of membrane biophysical properties [37].