The meta-analysis results of the effects of IF on the regulation of metabolic homeostasis in health and disease (T2D, MetS and obesity) were based on data from 47 studies selected considering the completeness of the outcomes measured in four main categories: adiposity (weight, BMI, waist circumference), lipid homeostasis (HDL-c, LDL-c, total cholesterol, triglycerides), insulin homeostasis (fasting glucose, fasting insulin, HOMA-IR) and blood pressure (SBP and DBP). The gene discussed is INS; the disease is Obesity.