On the other hand, cluster 2 contains KCTDs that are upregulated in B-ALL patients: KCTD3, KCTD5, KCTD10, KCTD12, KCTD13, KCTD15, KCTD18, and KCTD20. This evidence concerns the gene KCTD3 and precursor B-cell acute lymphoblastic leukemia.