The differential expression analysis between B-ALL samples and the B naïve healthy cells shows that KCTD3, KCTD10, KCTD12, and KCTD15 are significantly upregulated in the B-ALL patients, whereas KCTD7 and KCTD11 present increased expression levels in the healthy control (Figure 1B). The gene discussed is KCTD15; the disease is precursor B-cell acute lymphoblastic leukemia.