APOB and atherosclerosis: This provides the rationale for encouraging a healthy lifestyle to maintain low levels of Apo-A, Apo-B-containing lipoproteins throughout life to slow the progression of atherosclerosis; it also explains the motivation to recommend treatment to lower LDL-C and other Apo-B-containing lipoproteins, for both the primary prevention of ASCVD and the secondary prevention of recurrent CV events [83].