Consistently, Bai et al. confirmed the association of CC and CIN with folate deficiency (OR: 1.68 with serum level < 3.19 ng/mL), FHIT hypermethylation (OR: 11.47), and HPV HR infection (OR:4.63) with the progression of cervical lesions [65]. The gene discussed is FHIT; the disease is cervical squamous intraepithelial neoplasia.