Abnormal immune responses in the gut are a feature of colitis [35], which is characterized by the increase of inflammatory cytokines (TNF-α, IL-1β, IL-6, etc) and decrease of anti-inflammatory cytokines, such as IL-10, and these changes are observed in patients with IBD [36] and DSS-induced colitis mice [37]. This evidence concerns the gene IL10 and inflammatory bowel disease.